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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAdKd6IGwO6GITLG4DGYMbrm5nj1XNYkWy1ogAOo8x14s#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAdKd6IGwO6GITLG4DGYMbrm5nj1XNYkWy1ogAOo8x14s#_4 http://www.w3.org/ns/prov#value To test this hypothesis, we employed adenovirus-mediated gene transfer to express the Th1-affiliated, CXC chemokine IFN-gamma-inducible protein (IP) 10 in the airways of mice undergoing a mucosal sensitization regimen known to result in a Th2-polarized allergic response. This resulted in a approximately 60-75% inhibition of eosinophils in the bronchoalveolar lavage (BAL); these inflammatory changes were accompanied by enhanced IFN-gamma, ablated IL-4, and, peculiarly, unaltered IL-5 and eotaxin levels in the BAL. The effect of IP-10 expression was shown to be dependent on IFN-gamma, as there was no statistically significant reduction in BAL eosinophilia in IFN-gamma knockout mice subjected to the IP-10 intervention. http://www.tkuhn.ch/bel2nanopub/RAdKd6IGwO6GITLG4DGYMbrm5nj1XNYkWy1ogAOo8x14s#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11160341 http://www.tkuhn.ch/bel2nanopub/RAdKd6IGwO6GITLG4DGYMbrm5nj1XNYkWy1ogAOo8x14s#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAdKd6IGwO6GITLG4DGYMbrm5nj1XNYkWy1ogAOo8x14s#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11160341 http://www.tkuhn.ch/bel2nanopub/RAdKd6IGwO6GITLG4DGYMbrm5nj1XNYkWy1ogAOo8x14s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAdKd6IGwO6GITLG4DGYMbrm5nj1XNYkWy1ogAOo8x14s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAdKd6IGwO6GITLG4DGYMbrm5nj1XNYkWy1ogAOo8x14s#_4 http://www.tkuhn.ch/bel2nanopub/RAdKd6IGwO6GITLG4DGYMbrm5nj1XNYkWy1ogAOo8x14s#pubinfo http://www.tkuhn.ch/bel2nanopub/RAdKd6IGwO6GITLG4DGYMbrm5nj1XNYkWy1ogAOo8x14s http://purl.org/dc/terms/created 2014-07-03T14:29:54.015+02:00 http://www.tkuhn.ch/bel2nanopub/RAdKd6IGwO6GITLG4DGYMbrm5nj1XNYkWy1ogAOo8x14s http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAdKd6IGwO6GITLG4DGYMbrm5nj1XNYkWy1ogAOo8x14s http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234