@prefix dc1: <http://purl.org/dc/terms/> .
@prefix this: <http://purl.org/np/RAdasV-ISM_2N8Wp953PcAAbPPCIU6KwEfZ6Sg-Fkgvew> .
@prefix sub: <http://purl.org/np/RAdasV-ISM_2N8Wp953PcAAbPPCIU6KwEfZ6Sg-Fkgvew#> .
@prefix schema: <https://schema.org/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix nt: <https://w3id.org/np/o/ntemplate/> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix orcid: <https://orcid.org/> .
@prefix bl: <https://w3id.org/biolink/vocab/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
  <http://purl.obolibrary.org/obo/DOID_1724> bl:category bl:Disease .
  sub:association rdf:object <http://purl.obolibrary.org/obo/DOID_1724> ;
    rdf:predicate bl:treats ;
    rdf:subject <https://identifiers.org/drugbank:DB01129> ;
    a rdf:Statement ;
    rdfs:label "1 1 healing of erosive or ulcerative gerd in adults rabeprazole sodium delayed release tablets are indicated for short term 4 to 8 weeks treatment in the healing and symptomatic relief of erosive or ulcerative gastroesophageal reflux disease gerd for those patients who have not healed after 8 weeks of treatment an additional 8 week course of rabeprazole sodium delayed release tablets may be considered 1 2 maintenance of healing of erosive or ulcerative gerd in adults rabeprazole sodium delayed release tablets are indicated for maintaining healing and reduction in relapse rates of heartburn symptoms in patients with erosive or ulcerative gastroesophageal reflux disease gerd maintenance controlled studies do not extend beyond 12 months 1 3 treatment of symptomatic gerd in adults rabeprazole sodium delayed release tablets are indicated for the treatment of daytime and nighttime heartburn and other symptoms associated with gerd in adults for up to 4 weeks 1 4 healing of duodenal ulcers in adults rabeprazole sodium delayed release tablets are indicated for short term up to four weeks treatment in the healing and symptomatic relief of duodenal ulcers most patients heal within four weeks 1 5 helicobacter pylori eradication to reduce the risk of duodenal ulcer recurrence in adults rabeprazole sodium delayed release tablets in combination with amoxicillin and clarithromycin as a three drug regimen are indicated for the treatment of patients with h pylori infection and duodenal ulcer disease active or history within the past 5 years to eradicate h pylori eradication of h pylori has been shown to reduce the risk of duodenal ulcer recurrence see clinical studies 14 5 and dosage and administration 2 5 in patients who fail therapy susceptibility testing should be done if resistance to clarithromycin is demonstrated or susceptibility testing is not possible alternative antimicrobial therapy should be instituted see clinical pharmacology 12 2 and the clarithromycin package insert clinical pharmacology 12 2 1 6 treatment of pathological hypersecretory conditions including zollinger ellison syndrome in adults rabeprazole sodium delayed release tablets are indicated for the long term treatment of pathological hypersecretory conditions including zollinger ellison syndrome 1 7 short term treatment of symptomatic gerd in adolescent patients 12 years of age and older rabeprazole sodium delayed release tablets are indicated for the treatment of symptomatic gerd in adolescents 12 years of age and above for up to 8 weeks" ;
    bl:association_type bl:ChemicalToDiseaseOrPhenotypicFeatureAssociation ;
    bl:provided_by <https://w3id.org/um/NeuroDKG> ;
    bl:relation schema:TreatmentIndication .
  <https://identifiers.org/drugbank:DB01129> bl:category bl:Drug .
}
sub:provenance {
  sub:assertion prov:wasAttributedTo orcid:0000-0002-1468-3557 .
}
sub:pubinfo {
  sub:sig npx:hasAlgorithm "RSA" ;
    npx:hasPublicKey "MIGfMA0GCSqGSIb3DQEBAQUAA4GNADCBiQKBgQCODwZkXojpEKwk7Ldj2oPPfCstvqrcpgCaTLo235K7ht9C7E1GCkLvUuL2b4VWXJTcZx/hxgDauR8hUeYq/lS6tfTL9yFZsnfl+PWYDyz7vv6N+wJVx2LL8bO6ntCjcOzvW2t2WUeF12Sb6b3I6uOYP0N8iQKts1WasY/yEYKAHQIDAQAB" ;
    npx:hasSignature "LHRI4PATTQQ2rHIPSmVhjK7w+UzEcD476dECN8IXU2ROb2jg+JAsqqYjf2QA+XYaRBHj/amGeS4err2UYQrp/Eu0mgJVesUyKH5voU7AlkD6QUXtQJJ+xf4BihUNN/0e77fuXdMjcsbWlT/QBcYgnHtSXVroSJqvNIj0CIWYhrI=" ;
    npx:hasSignatureTarget this: .
  this: dc1:created "2021-06-14T08:31:29.099+02:00"^^xsd:dateTime ;
    dc1:creator orcid:0000-0002-1468-3557 ;
    nt:wasCreatedFromProvenanceTemplate <http://purl.org/np/RANwQa4ICWS5SOjw7gp99nBpXBasapwtZF1fIM3H2gYTM> ;
    nt:wasCreatedFromPubinfoTemplate <http://purl.org/np/RAA2MfqdBCzmz9yVWjKLXNbyfBNcwsMmOqcNUxkk1maIM> ;
    nt:wasCreatedFromTemplate <http://purl.org/np/RAManV5GZI01JKzW_IPcfOXoiFTcZMmsV7qTCLkdzr4Gs> .
}