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a plethora of kinases has been implicated in the phosphorylation of the enzyme 2 kinases, one dependent on cAMP, cAMPK, the other dependent on 5'-AMP, AMPK, can inactivate ACC by phosphorylation the cAMPK phosphorylates ACC at Ser77 and Ser1200 and causes primarily an increase in the Ka for citrate and a slight reduction in Vmax AMPK phosphorylates mainly at Ser79, Ser1200 and, to a lesser extent, at Ser1215 and produces a large decrease in Vmax the critical target for cAMPK appears to be Ser1200 and for AMPK, Ser79
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