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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAdsV9oklh5dfTQmYJRkrPpGHttp_nsdGHx_bu9_WHfJk#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAdsV9oklh5dfTQmYJRkrPpGHttp_nsdGHx_bu9_WHfJk#_3 http://www.w3.org/ns/prov#value Regarding the molecular mechanisms by which insulin/IGF-I elicit the positive effects on adipogenic differentiation, the IRS/PI3K signalling pathway plays a major role. Effective inhibitors of PI3K may help to define the role of this enzyme and its products in cells. In this regard, the use of two unrelated chemical inhibitors of PI3K enzymatic activity, wortmannin (a cell-permeable fungal metabolite that blocks the catalytic activity of the enzyme by interfering with p85-p110 interaction without affecting upstream signalling events) (Okada et al. 1994) and LY294002 (that acts on the ATP-binding site of the enzyme) (Vlahos et al. 1994), has allowed us to define the contribution of this pathway in inducing the expression of various metabolic genes. Experiments performed in our laboratory have shown that the expression of FAS and malic enzyme induced by IGF-I or insulin was completely prevented by treatment of primary brown adipocytes with either wortmannin or LY294002. http://www.tkuhn.ch/bel2nanopub/RAdsV9oklh5dfTQmYJRkrPpGHttp_nsdGHx_bu9_WHfJk#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15777261 http://www.tkuhn.ch/bel2nanopub/RAdsV9oklh5dfTQmYJRkrPpGHttp_nsdGHx_bu9_WHfJk#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAdsV9oklh5dfTQmYJRkrPpGHttp_nsdGHx_bu9_WHfJk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15777261 http://www.tkuhn.ch/bel2nanopub/RAdsV9oklh5dfTQmYJRkrPpGHttp_nsdGHx_bu9_WHfJk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAdsV9oklh5dfTQmYJRkrPpGHttp_nsdGHx_bu9_WHfJk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAdsV9oklh5dfTQmYJRkrPpGHttp_nsdGHx_bu9_WHfJk#_3 http://www.tkuhn.ch/bel2nanopub/RAdsV9oklh5dfTQmYJRkrPpGHttp_nsdGHx_bu9_WHfJk#pubinfo http://www.tkuhn.ch/bel2nanopub/RAdsV9oklh5dfTQmYJRkrPpGHttp_nsdGHx_bu9_WHfJk http://purl.org/dc/terms/created 2014-07-03T14:30:33.522+02:00 http://www.tkuhn.ch/bel2nanopub/RAdsV9oklh5dfTQmYJRkrPpGHttp_nsdGHx_bu9_WHfJk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAdsV9oklh5dfTQmYJRkrPpGHttp_nsdGHx_bu9_WHfJk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234