sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "We first determined whether Rac-1 is activated in NIH-3T3 cells allowed to adhere after presuspension. In agreement with previous reports (del Pozo et al., 2000), we observed an early accumulation of GTP-bound (i.e., active) Rac-1 upon cell plating on fibronectin with a kinetic comparable with the generation of oxygen species (Fig. 3 A). A causal link between Rac activation and adhesion-induced ROS was further demonstrated by overexpressing constitutively active Rac-1 mutant (RacQL) or the corresponding dominant-negative form (RacN17) of the GTPase (Fig. 3 B). As shown in Fig. 3 C, Rac-1?overexpressing cells plated on fibronectin produce significantly more hydrogen peroxide than cells in suspension. " ;
    prov:wasQuotedFrom pubmed:12796479 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:12796479 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}