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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAdt3L1op3NGsnjR4jp61jKjM07WiutYouF-s6bjSerd8#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAdt3L1op3NGsnjR4jp61jKjM07WiutYouF-s6bjSerd8#_4 http://www.w3.org/ns/prov#value We first determined whether Rac-1 is activated in NIH-3T3 cells allowed to adhere after presuspension. In agreement with previous reports (del Pozo et al., 2000), we observed an early accumulation of GTP-bound (i.e., active) Rac-1 upon cell plating on fibronectin with a kinetic comparable with the generation of oxygen species (Fig. 3 A). A causal link between Rac activation and adhesion-induced ROS was further demonstrated by overexpressing constitutively active Rac-1 mutant (RacQL) or the corresponding dominant-negative form (RacN17) of the GTPase (Fig. 3 B). As shown in Fig. 3 C, Rac-1?overexpressing cells plated on fibronectin produce significantly more hydrogen peroxide than cells in suspension. http://www.tkuhn.ch/bel2nanopub/RAdt3L1op3NGsnjR4jp61jKjM07WiutYouF-s6bjSerd8#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12796479 http://www.tkuhn.ch/bel2nanopub/RAdt3L1op3NGsnjR4jp61jKjM07WiutYouF-s6bjSerd8#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAdt3L1op3NGsnjR4jp61jKjM07WiutYouF-s6bjSerd8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12796479 http://www.tkuhn.ch/bel2nanopub/RAdt3L1op3NGsnjR4jp61jKjM07WiutYouF-s6bjSerd8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAdt3L1op3NGsnjR4jp61jKjM07WiutYouF-s6bjSerd8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAdt3L1op3NGsnjR4jp61jKjM07WiutYouF-s6bjSerd8#_4 http://www.tkuhn.ch/bel2nanopub/RAdt3L1op3NGsnjR4jp61jKjM07WiutYouF-s6bjSerd8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAdt3L1op3NGsnjR4jp61jKjM07WiutYouF-s6bjSerd8 http://purl.org/dc/terms/created 2014-07-03T14:30:13.450+02:00 http://www.tkuhn.ch/bel2nanopub/RAdt3L1op3NGsnjR4jp61jKjM07WiutYouF-s6bjSerd8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAdt3L1op3NGsnjR4jp61jKjM07WiutYouF-s6bjSerd8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234