@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAdu0FW_Hgbd2WTctzjjfOTmHArnm-lMgnXd0rS46r6BU> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAdu0FW_Hgbd2WTctzjjfOTmHArnm-lMgnXd0rS46r6BU#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix schem: <http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-chemical-names/> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix atcc: <http://www.lgcstandards-atcc.org/Products/All/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:1243;
    a RNA: .
  
  sub:_2 occursIn: mesh:D008264, atcc:CRL-1593.2.aspx, species:9606;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject schem:Low%20Density%20Lipoprotein;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(SCHEM:\"Low Density Lipoprotein\") -> r(HGNC:C1QBP)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "1.4" .
  
  sub:_3 prov:value "Table 4 Relative expression (RE) of 29 selected cellular genes in four study models by real-time RT-PCR - see comparisons below:  Model 2 (M2) values were normalized against the untreated control macrophages of model 1 (M1) at 24 h. Model 3 (M3) values were normalized against M1 at 72 h. Models 4 and 5 (M4 and M5) were normalized against M1 at 96 h.  M1@24, M1@72 and M1@96 denote control untreated macrophages whose RNAs were harvested and analyzed at 24, 72 and 96 h, respectively. M2@24 denotes LDL-treated macrophages with RNA analyzed at 24 h. M3@72 denotes macrophages infected with C. pneumoniae and RNA analyzed at 72 h. M4@96 denotes macrophages treated with LDL for 24 h, followed by C. pneumoniae infection for another 72 h before analyzing RNA at 96 h. M5@96 denotes macrophages infected with C. pneumoniae first for 72 h, followed by LDL treatment for another 24 h before analyzing RNA at 96 h. {for M4 and M5, results were combined and only the overlapping gene changes were modeled}  (from methods) The two-tailed t-test was then conducted to ascertain the statistical significance of the differences between the normalized relative expression values for each gene under the conditions stipulated for study models 2, 3, 4 and 5";
    prov:wasQuotedFrom pubmed:16466844 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:16466844;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:30:41.488+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}