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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAdxFK057NG4pfKTxWPC542Qgn7UzO-NSpZOwYzz_IXu4#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAdxFK057NG4pfKTxWPC542Qgn7UzO-NSpZOwYzz_IXu4#_5 http://www.w3.org/ns/prov#value MyD88-mediated NFkB activation is completely abolished in IRAK deficient I1A cells, Pellino 1-mediated NF?B activation is intact in these cells, indicating that Pellino 1 functions downstream of IRAK. On the other hand, Pellino 1-induced NFkB activation was inhibited by a dominant negative, kinase-inactive TAK1 mutant (TAK1 DN; Official Gene symbol - MAP3K7), indicating that Pellino1 must function upstream of TAK1 (Fig. 4 b). In support of this conclusion, TAK1 can still activate NFkB in C-12, where Pellino 1 expression is greatly knocked down by RNA interference (Fig. 4 c). Taken together, the above results support the hypothesis that the Pellino 1-IRAK-IRAK4-TRAF6 signaling complex functions between the receptor complex (Complex I) and the TAK1 complex (Complex II). http://www.tkuhn.ch/bel2nanopub/RAdxFK057NG4pfKTxWPC542Qgn7UzO-NSpZOwYzz_IXu4#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12496252 http://www.tkuhn.ch/bel2nanopub/RAdxFK057NG4pfKTxWPC542Qgn7UzO-NSpZOwYzz_IXu4#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAdxFK057NG4pfKTxWPC542Qgn7UzO-NSpZOwYzz_IXu4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12496252 http://www.tkuhn.ch/bel2nanopub/RAdxFK057NG4pfKTxWPC542Qgn7UzO-NSpZOwYzz_IXu4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAdxFK057NG4pfKTxWPC542Qgn7UzO-NSpZOwYzz_IXu4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAdxFK057NG4pfKTxWPC542Qgn7UzO-NSpZOwYzz_IXu4#_5 http://www.tkuhn.ch/bel2nanopub/RAdxFK057NG4pfKTxWPC542Qgn7UzO-NSpZOwYzz_IXu4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAdxFK057NG4pfKTxWPC542Qgn7UzO-NSpZOwYzz_IXu4 http://purl.org/dc/terms/created 2014-07-03T14:30:08.907+02:00 http://www.tkuhn.ch/bel2nanopub/RAdxFK057NG4pfKTxWPC542Qgn7UzO-NSpZOwYzz_IXu4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAdxFK057NG4pfKTxWPC542Qgn7UzO-NSpZOwYzz_IXu4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234