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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAe-f45TASS4XdRnnQ_lxP1CWxrhBUNtNg8wHFZlIr2qc#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAe-f45TASS4XdRnnQ_lxP1CWxrhBUNtNg8wHFZlIr2qc#_6 http://www.w3.org/ns/prov#value Small heterodimer partner (SHP; NR0B2), an exceptional member of the mammalian nuclear receptor family, directly modulates the activities of conventional nuclear receptors by acting as an inducible and tissue-specific corepressor. Recent progress in dissecting underlying molecular mechanisms, identifying target factors and target genes, and uncovering physiological functions points to the regulatory involvement of SHP in diverse metabolic and intracellular pathways that awaits future clarification. In this review, we carry out a comprehensive survey of all published data and discuss our current understanding of molecular mechanisms and physiological consequences governing SHP action. http://www.tkuhn.ch/bel2nanopub/RAe-f45TASS4XdRnnQ_lxP1CWxrhBUNtNg8wHFZlIr2qc#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16275121 http://www.tkuhn.ch/bel2nanopub/RAe-f45TASS4XdRnnQ_lxP1CWxrhBUNtNg8wHFZlIr2qc#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAe-f45TASS4XdRnnQ_lxP1CWxrhBUNtNg8wHFZlIr2qc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16275121 http://www.tkuhn.ch/bel2nanopub/RAe-f45TASS4XdRnnQ_lxP1CWxrhBUNtNg8wHFZlIr2qc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAe-f45TASS4XdRnnQ_lxP1CWxrhBUNtNg8wHFZlIr2qc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAe-f45TASS4XdRnnQ_lxP1CWxrhBUNtNg8wHFZlIr2qc#_6 http://www.tkuhn.ch/bel2nanopub/RAe-f45TASS4XdRnnQ_lxP1CWxrhBUNtNg8wHFZlIr2qc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAe-f45TASS4XdRnnQ_lxP1CWxrhBUNtNg8wHFZlIr2qc http://purl.org/dc/terms/created 2014-07-03T14:30:39.386+02:00 http://www.tkuhn.ch/bel2nanopub/RAe-f45TASS4XdRnnQ_lxP1CWxrhBUNtNg8wHFZlIr2qc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAe-f45TASS4XdRnnQ_lxP1CWxrhBUNtNg8wHFZlIr2qc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234