http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#Head http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#assertion http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#provenance http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#assertion http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_2 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=795 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_3 http://www.selventa.com/vocabulary/variantOf http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3585 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00696 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_3 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyIncreases http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_1 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(HGNC:ATM)) => p(HGNC:FANCD2,pmod(P,S,222)) http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_5 http://www.w3.org/ns/prov#value There is evidence that FANCD2,like BRCA1, participates in the events that are triggered by DNA damage during S and G2 phases and that lead to cell-cycle arrest. As well as modifying BRCA1, the ATM protein kinase can phosphorylate FANCD2 on several residues, including serine 222, following exposure to ionizing radiation77. Ser222 phosphorylation is required for the intra-S-phase arrest and is, in turn, dependent on the protein kinase NBS1, which is a component of the trimeric MRE11-RAD50-NBS1 complex78. FANCD2 can also be phosphorylated in an ATM-independent manner by the ATR kinase79,which signals an intra-S-phase arrest that is triggered by ultraviolet radiation or DNA-crosslinking agents46.Here, too, FANCD2 phosphorylation depends on NBS1, which is required to fully enforce the S-phase checkpoint. The participation of FANCD2 in ionizingradiation- activated checkpoint responses through phosphorylation on Ser222 seems to be independent78 of its mono-ubiquitylation on Lys561, which promotes the translocation of FANCD2 to damage-induced nuclear foci that contain BRCA1 and RAD51, and that are presumed sites of DNA repair. Similarly, FANCD2 foci do not require ATR-dependent phosphorylation79. http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15057286 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15057286 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#_5 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw http://purl.org/dc/terms/created 2014-07-03T14:30:22.194+02:00 http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAe1bq-ZnDMl2apBFQmO3E-ViqIMReQkGXIKPRD0_1JFw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234