sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "Ppara ligands decrease cytokine-mediated Vcam1 expression through effects on Nfkb signaling. Mechanisms involved reportedly include direct Ppara interaction with p65 and Ppara dependent expression of Ikba, sequestering the inactive p65/p50 complex in the cytoplasm. % These studies provide evidence that LPL acts on LDL(-) to generate Ppara ligands, thus countering the endothelial adhesion molecule expression induced by LDL(-) alone...In contrast, LPL hydrolysis of LDL(-) limits these responses by generation PPARa ligands, increasing IkBa expression with subsequent Nfkb inhibition.% LPL-treated LDL(-) suppressed NFkB and AP-1 activation, increasing expression of the PPARa target gene IkBalpha, although only in the genetic presence of PPARa and with intact LPL hydrolysis." ;
    prov:wasQuotedFrom pubmed:12878589 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:12878589 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}