. . . . . . . . . . . . . . . "p(MGI:Nfkbia) -| tscript(complex(NCM:\"Nfkb Complex\"))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Ppara ligands decrease cytokine-mediated Vcam1 expression through effects on Nfkb signaling. Mechanisms involved reportedly include direct Ppara interaction with p65 and Ppara dependent expression of Ikba, sequestering the inactive p65/p50 complex in the cytoplasm. % These studies provide evidence that LPL acts on LDL(-) to generate Ppara ligands, thus countering the endothelial adhesion molecule expression induced by LDL(-) alone...In contrast, LPL hydrolysis of LDL(-) limits these responses by generation PPARa ligands, increasing IkBa expression with subsequent Nfkb inhibition.% LPL-treated LDL(-) suppressed NFkB and AP-1 activation, increasing expression of the PPARa target gene IkBalpha, although only in the genetic presence of PPARa and with intact LPL hydrolysis." . . "Selventa" . . . . "2014-07-03T14:30:14.912+02:00"^^ . . .