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p(HGNC:VHL) -> p(HGNC:FN1)
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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1.4
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Several reports have demonstrated that the inactivation of pVHL tumour suppressor function is linked to abnormal extracellular fibronectin arrays in both RCC cells that lack functional pVHL and VHLK-K mouse fibroblasts [44 to 46]. However, the exact nature of such an association and the mechanism by which VHL regulates the assembly of this ECM remain poorly understood. Nevertheless, the restored ability of pVHL-positive transfectants to assemble extracellular fibronectin was mediated by b1 integrins, implying that pVHL controls ECM assembly, at least in part, through integrin signalling [46].
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Selventa
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2014-07-03T14:30:27.343+02:00
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