[ {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q",
    "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ],
    "http://www.nanopub.org/nschema#hasAssertion" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#assertion"
    } ],
    "http://www.nanopub.org/nschema#hasProvenance" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#provenance"
    } ],
    "http://www.nanopub.org/nschema#hasPublicationInfo" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#pubinfo"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#Head"
}, {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_1",
    "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ],
    "http://purl.obolibrary.org/obo/RO_0002204" : [ {
      "@id" : "http://www.informatics.jax.org/marker/MGI:98872"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_2",
    "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ],
    "http://purl.obolibrary.org/obo/BFO_0000066" : [ {
      "@id" : "http://www.lgcstandards-atcc.org/Products/All/CCL-92.aspx"
    }, {
      "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ {
      "@id" : "http://purl.bioontology.org/ontology/MSH/D017209"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ {
      "@id" : "http://www.selventa.com/vocabulary/decreases"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_1"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#assertion",
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "p(MGI:Twist1) -| bp(MESHPP:Apoptosis)"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#assertion"
}, {
  "@graph" : [ {
    "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel",
    "http://purl.org/dc/elements/1.1/description" : [ {
      "@value" : "Approximately 61,000 statements."
    } ],
    "http://purl.org/dc/elements/1.1/rights" : [ {
      "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved."
    } ],
    "http://purl.org/dc/elements/1.1/title" : [ {
      "@value" : "BEL Framework Large Corpus Document"
    } ],
    "http://purl.org/pav/authoredBy" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_4"
    } ],
    "http://purl.org/pav/version" : [ {
      "@value" : "1.4"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_3",
    "http://www.w3.org/ns/prov#value" : [ {
      "@value" : "In this study we investigated the molecular mechanisms whereby insulin-like growth factor 1 (IGF-1) induced Twist gene expression and the role of Twist in the anti-apoptotic actions of the IGF-1 receptor. In NIH-3T3 fibroblasts overexpressing the human IGF-1 receptor (NWTb3), treatment with IGF-1 (10(-8) m) for 1 and 4 h increased the level of Twist mRNA as well as protein by 3-fold. In contrast, insulin at physiological concentrations did not stimulate Twist expression in NIH-3T3 fibroblasts overexpressing the human insulin receptor. The IGF-1 effect was specific for the IGF-1 receptor since, in cells overexpressing a dominant negative IGF-1 receptor, IGF-1 failed to increase Twist expression. Pre-incubation with the ERK1/2 inhibitor U0126 or expression of a dominant negative MEK-1 abolished the effect of IGF-1 on Twist mRNA expression in NWTb3 cells, suggesting that Twist induction by IGF-1 occurs via the mitogen-activated protein kinase signaling pathway. In vivo, IGF-1 injection increased the mRNA level of Twist in mouse skeletal muscle, the major site of Twist expression. Finally, using an antisense strategy, we demonstrated that a reduction of 40% in Twist expression decreased significantly the ability of IGF-1 to rescue NWTb3 cells from etoposide-induced apoptosis. Taken together, these results define Twist as an important factor involved in the anti-apoptotic actions of the IGF-1 receptor."
    } ],
    "http://www.w3.org/ns/prov#wasQuotedFrom" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/11323435"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_4",
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "Selventa"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#assertion",
    "http://www.w3.org/ns/prov#hadPrimarySource" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/11323435"
    } ],
    "http://www.w3.org/ns/prov#wasDerivedFrom" : [ {
      "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel"
    }, {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_3"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#provenance"
}, {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q",
    "http://purl.org/dc/terms/created" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#dateTime",
      "@value" : "2014-07-03T14:29:55.757+02:00"
    } ],
    "http://purl.org/pav/createdBy" : [ {
      "@id" : "http://orcid.org/0000-0001-6818-334X"
    }, {
      "@id" : "http://orcid.org/0000-0002-1267-0234"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#pubinfo"
} ]