http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#Head http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#assertion http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#provenance http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#pubinfo http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#assertion http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:98872 http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.lgcstandards-atcc.org/Products/All/CCL-92.aspx http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://purl.bioontology.org/ontology/MSH/D017209 http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_1 http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#assertion http://www.w3.org/2000/01/rdf-schema#label p(MGI:Twist1) -| bp(MESHPP:Apoptosis) http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_3 http://www.w3.org/ns/prov#value In this study we investigated the molecular mechanisms whereby insulin-like growth factor 1 (IGF-1) induced Twist gene expression and the role of Twist in the anti-apoptotic actions of the IGF-1 receptor. In NIH-3T3 fibroblasts overexpressing the human IGF-1 receptor (NWTb3), treatment with IGF-1 (10(-8) m) for 1 and 4 h increased the level of Twist mRNA as well as protein by 3-fold. In contrast, insulin at physiological concentrations did not stimulate Twist expression in NIH-3T3 fibroblasts overexpressing the human insulin receptor. The IGF-1 effect was specific for the IGF-1 receptor since, in cells overexpressing a dominant negative IGF-1 receptor, IGF-1 failed to increase Twist expression. Pre-incubation with the ERK1/2 inhibitor U0126 or expression of a dominant negative MEK-1 abolished the effect of IGF-1 on Twist mRNA expression in NWTb3 cells, suggesting that Twist induction by IGF-1 occurs via the mitogen-activated protein kinase signaling pathway. In vivo, IGF-1 injection increased the mRNA level of Twist in mouse skeletal muscle, the major site of Twist expression. Finally, using an antisense strategy, we demonstrated that a reduction of 40% in Twist expression decreased significantly the ability of IGF-1 to rescue NWTb3 cells from etoposide-induced apoptosis. Taken together, these results define Twist as an important factor involved in the anti-apoptotic actions of the IGF-1 receptor. http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11323435 http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11323435 http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#_3 http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q#pubinfo http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q http://purl.org/dc/terms/created 2014-07-03T14:29:55.757+02:00 http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAeHjh11-h0lLfou1TvU4_INzUGsi0g14UOGlXFzx7f_Q http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234