http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#Head http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#assertion http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#provenance http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#assertion http://resource.belframework.org/belframework/1.0/namespace/selventa-named-mouse-complexes/Nfkb%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_1 http://semanticscience.org/resource/SIO_000139 http://resource.belframework.org/belframework/1.0/namespace/selventa-named-mouse-complexes/Nfkb%20Complex http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:1338762 http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D015603 http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_2 http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_1 http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#assertion http://www.w3.org/2000/01/rdf-schema#label tscript(complex(NCM:"Nfkb Complex")) -> r(MGI:Fhl2) http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_4 http://www.w3.org/ns/prov#value We reported previously that transcription factor nuclear factor (NF)-kappaB is constitutively activated in human and murine squamous cell carcinomas (SCCs). The role of NF-kappaB in the cumulative changes in gene expression with transformation and progression of the murine SCC Pam 212 and after switching off NF-kappaB by a dominant negative inhibitor kappaB mutant (IkappaBalphaM) was explored by profiling with a 15,000-element cDNA micoarrray. Remarkably, NF-kappaB modulated the expression of 60% of the 308 genes differentially expressed between normal keratinocytes and metastatic SCCs. NF-kappaB directly or indirectly modulated expression of programs of genes functionally linked to proliferation, apoptosis, adhesion, and angiogenesis. Among these, changes in expression of cyclin D1, inhibitor of apoptosis-1, mutant Trp53, and beta-catenin detected with modulation of NF-kappaB by microarray were confirmed by Western and Northern blot. NF-kappaB DNA binding motifs were detected in the promoter of approximately 63% of genes showing increased expression and 33% of the genes showing decreased expression. The ACTACAG motif implicated in the NF-kappaB-dependent down-regulation of mRNA expression of MyoD and Sox9 was detected in the coding portion of about 15% of genes showing increased or decreased expression. Inactivation of NF-kappaB inhibited malignant phenotypic features including proliferation, cell survival, migration, angiogenesis, and tumorigenesis. These results provide evidence that NF-kappaB is an important modulator of gene expression programs that contribute to the malignant phenotype of SCC. http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15374962 http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15374962 http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#_4 http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM http://purl.org/dc/terms/created 2014-07-03T14:30:27.784+02:00 http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAeRL-Q3ydFUZsS-ef_gIDzKZE3N-rUR_F2h4AnGpTJdM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234