@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAeS8pcC_GWKzP5U9oLtoI4YHfXk7-R-iaedJvUBCPRWA> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAeS8pcC_GWKzP5U9oLtoI4YHfXk7-R-iaedJvUBCPRWA#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:10672;
    a Protein: .
  
  sub:_2 hasAgent: sub:_3;
    a go:0003824 .
  
  sub:_3 geneProductOf: hgnc:2561;
    a Protein: .
  
  sub:_4 hasAgent: sub:_5;
    a go:0016301 .
  
  sub:_5 geneProductOf: hgnc:391;
    a Protein: .
  
  sub:_6 rdf:object sub:_4;
    rdf:predicate belv:increases;
    rdf:subject sub:_2;
    a rdf:Statement .
  
  sub:_7 occursIn: mesh:D001921, species:9606;
    rdf:object sub:_6;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "cat(p(HGNC:CXCR4)) -> kin(p(HGNC:AKT1))", "p(HGNC:CXCL12) -> (cat(p(HGNC:CXCR4)) -> kin(p(HGNC:AKT1)))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_9;
    pav:version "1.4" .
  
  sub:_8 prov:value "We used phosphospecific antibodies to Erk1/2 and Akt (protein kinase B) to determine whether these pathways are activated in response to CXCL12 in brain tumor cells. CXCL12 stimulates activation of Erk1/2 and Akt in both medulloblastoma and glioblastoma cells (Fig. 6, which is published as supporting information on the PNAS web site). In both Daoy and U87 cells, these rapid responses to CXCL12 are attenuated by AMD 3100.";
    prov:wasQuotedFrom pubmed:14595012 .
  
  sub:_9 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:14595012;
    prov:wasDerivedFrom beldoc:, sub:_8 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:30:18.010+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}