http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#Head http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#assertion http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#provenance http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#assertion http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11639 http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#_2 http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11556 http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#assertion http://www.w3.org/2000/01/rdf-schema#label complex(p(HGNC:TAL1),g(HGNC:TCF7)) http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#_3 http://www.w3.org/ns/prov#value Aberrant expression of 1 or more transcription factor oncogenes is a critical component of the molecular pathogenesis of human T-cell acute lymphoblastic leukemia (T-ALL); however, oncogenic transcriptional programs downstream of T-ALL oncogenes are mostly unknown. TAL1/SCL is a basic helix-loop-helix (bHLH) transcription factor oncogene aberrantly expressed in 60% of human T-ALLs. We used chromatin immunoprecipitation (ChIP) on chip to identify 71 direct transcriptional targets of TAL1/SCL. Promoters occupied by TAL1 were also frequently bound by the class I bHLH proteins E2A and HEB, suggesting that TAL1/E2A as well as TAL1/HEB heterodimers play a role in transformation of T-cell precursors. Using RNA interference, we demonstrated that TAL1 is required for the maintenance of the leukemic phenotype in Jurkat cells and showed that TAL1 binding can be associated with either repression or activation of genes whose promoters occupied by TAL1, E2A, and HEB. In addition, oligonucleotide microarray analysis of RNA from 47 primary T-ALL samples showed specific expression signatures involving TAL1 targets in TAL1-expressing compared with -nonexpressing human T-ALLs. Our results indicate that TAL1 may act as a bifunctional transcriptional regulator (activator and repressor) at the top of a complex regulatory network that disrupts normal T-cell homeostasis and contributes to leukemogenesis. http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16621969 http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16621969 http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#_3 http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw http://purl.org/dc/terms/created 2014-07-03T14:30:42.743+02:00 http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAeuaO_Yr7i3-w5SXW4xXLCqjKwCzgjYblPGL-fLqCUQw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234