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http://purl.obolibrary.org/obo/BFO_0000066
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p(HGNC:EGF) -| p(HGNC:EGFR)
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p(HGNC:LRIG1) => (p(HGNC:EGF) -| p(HGNC:EGFR))
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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1.4
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In the experiment illustrated in Fig. 5B, PC3-LRIG1 cells were treated with and without tetracycline to induce LRIG1 expression, and a time course of EGF stimulation of the cells was carried out. Lysates were immunoblotted with anti-phosphotyrosine and anti-EGFR antibodies. In the presence of LRIG1, EGFR responded less efficiently to EGF as determined by blotting autophosphorylated receptors with anti-phosphotyrosine. Interestingly, LRIG1 expression also resulted in an accelerated loss of EGFR.
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Selventa
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2014-07-03T14:30:27.321+02:00
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