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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAf8S_SQHR-RTLJVSjvq4cF_HFQS61FNYPMjl5E1NmjJI#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAf8S_SQHR-RTLJVSjvq4cF_HFQS61FNYPMjl5E1NmjJI#_5 http://www.w3.org/ns/prov#value Nrf1 and Nrf2 Regulate a Similar Subset of Antioxidant Genes: Expression of Gclm was reduced to the same extent in both Nrf1 and Nrf2 mutant cells. NQO1 was down-regulated to a similar extent in both single mutant cells, whereas mRNA levels of heme-oxygenase-1 (HO-1), ferritin-H (FtH), and metallothionein-1 (MT-1) was lower in nrf2–/– cells compared with nrf1–/– cells (Fig. 6a). 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