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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAfDLsxYBS8FaTtG1CIGwArj4SVe9MDxiKJa8l_vmh-vQ#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAfDLsxYBS8FaTtG1CIGwArj4SVe9MDxiKJa8l_vmh-vQ#_3 http://www.w3.org/ns/prov#value Overexpressed Gpx4 approximately threefold, the conversion of arachidonic acid to intermediates in the lipoxygenase pathway was inhibited eightfold (leukotriene C4 and leukotriene B4). Normal rates of leukotriene C4 formation were restored in the transfected cell by treatment with the inhibitor diethylmalate, which decreases GPX4 activity...The authors concluded that Gpx4 deactivated 5-lipoxygenase via decreases in levels of hydroperoxides required for activation of the enzyme. http://www.tkuhn.ch/bel2nanopub/RAfDLsxYBS8FaTtG1CIGwArj4SVe9MDxiKJa8l_vmh-vQ#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11215509 http://www.tkuhn.ch/bel2nanopub/RAfDLsxYBS8FaTtG1CIGwArj4SVe9MDxiKJa8l_vmh-vQ#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAfDLsxYBS8FaTtG1CIGwArj4SVe9MDxiKJa8l_vmh-vQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11215509 http://www.tkuhn.ch/bel2nanopub/RAfDLsxYBS8FaTtG1CIGwArj4SVe9MDxiKJa8l_vmh-vQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAfDLsxYBS8FaTtG1CIGwArj4SVe9MDxiKJa8l_vmh-vQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAfDLsxYBS8FaTtG1CIGwArj4SVe9MDxiKJa8l_vmh-vQ#_3 http://www.tkuhn.ch/bel2nanopub/RAfDLsxYBS8FaTtG1CIGwArj4SVe9MDxiKJa8l_vmh-vQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAfDLsxYBS8FaTtG1CIGwArj4SVe9MDxiKJa8l_vmh-vQ http://purl.org/dc/terms/created 2014-07-03T14:29:54.326+02:00 http://www.tkuhn.ch/bel2nanopub/RAfDLsxYBS8FaTtG1CIGwArj4SVe9MDxiKJa8l_vmh-vQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAfDLsxYBS8FaTtG1CIGwArj4SVe9MDxiKJa8l_vmh-vQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234