. . . . . . . . . . . . . "a(CHEBI:\"hyaluronic acid\") -> p(HGNC:ESR1,pmod(P,S,118))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "In searching for a possible linkage between HA-CD44-mediated IQGAP1 signaling and ERK and ER{alpha} function, we demonstrated that IQGAP1-linked ERK2 isolated from SK-OV-3.ipl cells treated with HA was capable of phosphorylating ER{alpha} in vitro (Fig. 5A, bar b). EGF stimulation of MAPKs such as ERK1 and ERK2 has been shown to phosphorylate ER{alpha} at Ser118 in the N-terminal domain and to enhance transcriptional activity. ER{alpha} phosphorylation in vivo (as detected by anti-phospho-ER{alpha} antibody (Ser118)) was also greatly enhanced in SK-OV-3.ipl cells treated with HA.The level of ERE gene activity was low in untreated cells (bar a) or in cells pretreated with anti-CD44 antibody, followed by HA treatment (bar c). ERE gene activity was greatly enhanced in SK-OV-3.ipl cells treated with intact HA" . . "Selventa" . . . . "2014-07-03T14:30:30.944+02:00"^^ . . .