@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAfOFWXVo3a_vZGFgokRPX70xqBYhp3VP7h3EgtnG0CBc> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAfOFWXVo3a_vZGFgokRPX70xqBYhp3VP7h3EgtnG0CBc#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix proteinModification: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000> .
@prefix psimod: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 belv:variantOf hgnc:3467;
    a proteinModification:, psimod:00696 .
  
  sub:_2 occursIn: mesh:D010053, species:9606;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject chebi:5772;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(CHEBI:\"hyaluronic acid\") -> p(HGNC:ESR1,pmod(P,S,118))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "1.4" .
  
  sub:_3 prov:value "In searching for a possible linkage between HA-CD44-mediated IQGAP1 signaling and ERK and ER{alpha} function, we demonstrated that IQGAP1-linked ERK2 isolated from SK-OV-3.ipl cells treated with HA was capable of phosphorylating ER{alpha} in vitro (Fig. 5A, bar b). EGF stimulation of MAPKs such as ERK1 and ERK2 has been shown to phosphorylate ER{alpha} at Ser118 in the N-terminal domain and to enhance transcriptional activity. ER{alpha} phosphorylation in vivo (as detected by anti-phospho-ER{alpha} antibody (Ser118)) was also greatly enhanced in SK-OV-3.ipl cells treated with HA.The level of ERE gene activity was low in untreated cells (bar a) or in cells pretreated with anti-CD44 antibody, followed by HA treatment (bar c). ERE gene activity was greatly enhanced in SK-OV-3.ipl cells treated with intact HA";
    prov:wasQuotedFrom pubmed:15655247 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:15655247;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:30:30.944+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}