. . . . . . . . . . . . . . . "tscript(p(HGNC:MEF2C)) -> r(HGNC:PPARGC1A)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Although CREB thus seems to be an important factor in the induction of PGC-1-alpha , the increased effect of CaMKIV in combination with CnA suggests that factors in addition to CREB are likely to be involved in the transcription of the PGC-1-alpha gene in muscle. Because MEF2 and NFAT transcription factors are known targets of CaMKIV and CnA in muscle fiber-type determination, we tested the role of these factors in the control of the PGC-1-alpha promoter. MEF2C, MEF2D, or NFATc3 alone did not have a significant effect on the function of the 2-kb PGC-1-alpha promoter (Fig. 2A). However, because MEF2 proteins are known to be coactivated by PGC-1-alpha (7), we also tested these factors in cotransfection experiments. As shown in Fig. 2A, a coactivation by PGC-1-alpha of both MEF2C and MEF2D, but not NFAT, was observed on the PGC-1-alpha promoter. These data suggest that PGC-1-alpha might participate in the activation of its own promoter and that the MEF2 proteins may function both in the regulation of PGC-1-alpha expression and as downstream targets of PGC-1-alpha coactivation of other muscle-selective genes." . . "Selventa" . . . . "2014-07-03T14:30:12.659+02:00"^^ . . .