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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAfTVeQFUrIFRjwLCvQa4V00Pey0E_TunxZGxPQDi2a5E#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAfTVeQFUrIFRjwLCvQa4V00Pey0E_TunxZGxPQDi2a5E#_5 http://www.w3.org/ns/prov#value Although CREB thus seems to be an important factor in the induction of PGC-1-alpha , the increased effect of CaMKIV in combination with CnA suggests that factors in addition to CREB are likely to be involved in the transcription of the PGC-1-alpha gene in muscle. Because MEF2 and NFAT transcription factors are known targets of CaMKIV and CnA in muscle fiber-type determination, we tested the role of these factors in the control of the PGC-1-alpha promoter. MEF2C, MEF2D, or NFATc3 alone did not have a significant effect on the function of the 2-kb PGC-1-alpha promoter (Fig. 2A). However, because MEF2 proteins are known to be coactivated by PGC-1-alpha (7), we also tested these factors in cotransfection experiments. As shown in Fig. 2A, a coactivation by PGC-1-alpha of both MEF2C and MEF2D, but not NFAT, was observed on the PGC-1-alpha promoter. These data suggest that PGC-1-alpha might participate in the activation of its own promoter and that the MEF2 proteins may function both in the regulation of PGC-1-alpha expression and as downstream targets of PGC-1-alpha coactivation of other muscle-selective genes. http://www.tkuhn.ch/bel2nanopub/RAfTVeQFUrIFRjwLCvQa4V00Pey0E_TunxZGxPQDi2a5E#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12764228 http://www.tkuhn.ch/bel2nanopub/RAfTVeQFUrIFRjwLCvQa4V00Pey0E_TunxZGxPQDi2a5E#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAfTVeQFUrIFRjwLCvQa4V00Pey0E_TunxZGxPQDi2a5E#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12764228 http://www.tkuhn.ch/bel2nanopub/RAfTVeQFUrIFRjwLCvQa4V00Pey0E_TunxZGxPQDi2a5E#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAfTVeQFUrIFRjwLCvQa4V00Pey0E_TunxZGxPQDi2a5E#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAfTVeQFUrIFRjwLCvQa4V00Pey0E_TunxZGxPQDi2a5E#_5 http://www.tkuhn.ch/bel2nanopub/RAfTVeQFUrIFRjwLCvQa4V00Pey0E_TunxZGxPQDi2a5E#pubinfo http://www.tkuhn.ch/bel2nanopub/RAfTVeQFUrIFRjwLCvQa4V00Pey0E_TunxZGxPQDi2a5E http://purl.org/dc/terms/created 2014-07-03T14:30:12.659+02:00 http://www.tkuhn.ch/bel2nanopub/RAfTVeQFUrIFRjwLCvQa4V00Pey0E_TunxZGxPQDi2a5E http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAfTVeQFUrIFRjwLCvQa4V00Pey0E_TunxZGxPQDi2a5E http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234