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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAfeuEOlDgY_mldQ4Mz0Ezz2drh5ZO-hv82pNIfhpa7Nw#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAfeuEOlDgY_mldQ4Mz0Ezz2drh5ZO-hv82pNIfhpa7Nw#_3 http://www.w3.org/ns/prov#value Cachexia-induced hypoalbuminemia is mediated by tumor necrosis factor (TNF)-alpha. In turn, TNF-alpha stimulates oxidative stress, NO synthesis, and phosphorylation of C/EBP-beta within its nuclear localization signal (NLS). Consequently, C/EBP-beta is exported from the nucleus, preventing it to act as a transcriptional factor on the albumin gene. http://www.tkuhn.ch/bel2nanopub/RAfeuEOlDgY_mldQ4Mz0Ezz2drh5ZO-hv82pNIfhpa7Nw#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15758650 http://www.tkuhn.ch/bel2nanopub/RAfeuEOlDgY_mldQ4Mz0Ezz2drh5ZO-hv82pNIfhpa7Nw#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAfeuEOlDgY_mldQ4Mz0Ezz2drh5ZO-hv82pNIfhpa7Nw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15758650 http://www.tkuhn.ch/bel2nanopub/RAfeuEOlDgY_mldQ4Mz0Ezz2drh5ZO-hv82pNIfhpa7Nw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAfeuEOlDgY_mldQ4Mz0Ezz2drh5ZO-hv82pNIfhpa7Nw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAfeuEOlDgY_mldQ4Mz0Ezz2drh5ZO-hv82pNIfhpa7Nw#_3 http://www.tkuhn.ch/bel2nanopub/RAfeuEOlDgY_mldQ4Mz0Ezz2drh5ZO-hv82pNIfhpa7Nw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAfeuEOlDgY_mldQ4Mz0Ezz2drh5ZO-hv82pNIfhpa7Nw http://purl.org/dc/terms/created 2014-07-03T14:30:33.393+02:00 http://www.tkuhn.ch/bel2nanopub/RAfeuEOlDgY_mldQ4Mz0Ezz2drh5ZO-hv82pNIfhpa7Nw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAfeuEOlDgY_mldQ4Mz0Ezz2drh5ZO-hv82pNIfhpa7Nw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234