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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAfiEVP-d9rheGs3HaR9j7ZE97IviCNOUpziPEA-8Rfmg#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAfiEVP-d9rheGs3HaR9j7ZE97IviCNOUpziPEA-8Rfmg#_6 http://www.w3.org/ns/prov#value Despite such multiple target interactions of Akt1, parallel coinhibition of Akt1 and Par-4 expression by RNA interference resulted in the inhibition of apoptosis, indicating the failure of the other Akt1 substrates to induce apoptosis in the absence of Par-4 expression or function. Moreover, coinhibition of Akt1 and other Akt1 substrates did not inhibit apoptosis, implying that the observed apoptosis upon Akt1 inhibition can be ascribed primarily to Par-4. 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