http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#Head http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#assertion http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#provenance http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#assertion http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_2 http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.ncbi.nlm.nih.gov/gene/2475 http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_3 http://www.selventa.com/vocabulary/variantOf http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-protein-families/AKT%20Family http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000 http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00696 http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_3 http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyIncreases http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_1 http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(EGID:2475)) => p(PFH:"AKT Family",pmod(P,S,473)) http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_5 http://www.w3.org/ns/prov#value We found that rictor immunopurifications contain isoforms 1, 2, and 5 (Figure 2C, left panel). mTOR immunopurifications also contain each of these isoforms (data not shown), whereas raptor immunopurifications do not (Figure 2C, right panel). In agreement with these findings, immunopurifications of myc-tagged isoforms 1, 2, and 5 coimmunoprecipitate mTOR and rictor but not raptor (Figure 2D, left panels). Knockdown of mSin1 with these two different shRNAs severely inhibited the phosphorylation of Ser473-Akt/PKB without affecting that of Thr389 of S6K1. We observed the same effect by knocking down rictor, whereas a control shRNA had no effect on Akt/PKB. http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16919458 http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16919458 http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#_5 http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ http://purl.org/dc/terms/created 2014-07-03T14:30:45.625+02:00 http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAfl2v3dVhQ4Cu0OOLjGAyECjSmkYApa9sgqEWDPVZVmQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234