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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAfq03G9UxW_Pyix8DVQZ9sQYPF9J_95mnN46m97dLsYA#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAfq03G9UxW_Pyix8DVQZ9sQYPF9J_95mnN46m97dLsYA#_4 http://www.w3.org/ns/prov#value We have developed a model system to analyze the effects of DNA methyltransferase 1 (Dnmt1) deficiency on DNA mismatch repair (MMR) in mouse embryonic stem (ES) cells. We found that Dnmt1 deficiency led to a 7-fold increase in the microsatellite slippage rate. Interestingly, the region flanking the mononucleotide repeat was unmethylated regardless of Dnmt1 status, suggesting that it is not the local levels of DNA methylation that direct the increase in microsatellite instability (MSI). The enhanced MSI was associated with higher levels of histone H3 acetylation and lower MeCP2 binding at regions near the assayed microsatellite, suggesting that Dnmt1 loss may decrease MMR efficiency by modifying chromatin structure. http://www.tkuhn.ch/bel2nanopub/RAfq03G9UxW_Pyix8DVQZ9sQYPF9J_95mnN46m97dLsYA#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15509869 http://www.tkuhn.ch/bel2nanopub/RAfq03G9UxW_Pyix8DVQZ9sQYPF9J_95mnN46m97dLsYA#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAfq03G9UxW_Pyix8DVQZ9sQYPF9J_95mnN46m97dLsYA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15509869 http://www.tkuhn.ch/bel2nanopub/RAfq03G9UxW_Pyix8DVQZ9sQYPF9J_95mnN46m97dLsYA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAfq03G9UxW_Pyix8DVQZ9sQYPF9J_95mnN46m97dLsYA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAfq03G9UxW_Pyix8DVQZ9sQYPF9J_95mnN46m97dLsYA#_4 http://www.tkuhn.ch/bel2nanopub/RAfq03G9UxW_Pyix8DVQZ9sQYPF9J_95mnN46m97dLsYA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAfq03G9UxW_Pyix8DVQZ9sQYPF9J_95mnN46m97dLsYA http://purl.org/dc/terms/created 2014-07-03T14:30:28.980+02:00 http://www.tkuhn.ch/bel2nanopub/RAfq03G9UxW_Pyix8DVQZ9sQYPF9J_95mnN46m97dLsYA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAfq03G9UxW_Pyix8DVQZ9sQYPF9J_95mnN46m97dLsYA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234