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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAfuJKOrH4EmC0SD16zGhlgB-lfiWWqY-BhsncLPHa9IY#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAfuJKOrH4EmC0SD16zGhlgB-lfiWWqY-BhsncLPHa9IY#_5 http://www.w3.org/ns/prov#value Mice homozygous for a tyr757-to-phe (Y757F) mutation, which inactivated the Shp2-binding domain of gp130, developed normally into superficially healthy adults, but they showed age-dependent enlargement of the stomach, proximal small intestine, and spleen. Histologic examination revealed hyperproliferative lesions within the antropyloric mucosa, often circumferential, resulting in gastric outlet obstruction. 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