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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAg25eB99HY4m6FsmyxIAjqfHo3diYVC88b6J5TkKRT84#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAg25eB99HY4m6FsmyxIAjqfHo3diYVC88b6J5TkKRT84#_5 http://www.w3.org/ns/prov#value Jagged1 on tumor cells binds to Notch receptor(s) on endothelial cells. Upon ligand binding, the Notch intracellular domain (NICD) is released from the endothelial cell plasma membrane by the secretase-dependent proteolytic cleavages of Notch receptor. The NICD then translocates to the nucleus, where it interacts with the CSL (named for mammalian CBF1/RBP, Drosophila Su(H), and C. elegans Lag-1) transcription repressor to activate the transcription of target genes.The basic-helix-loop-helix proteins (bHLH) Hairy/Enhancer of Split (Hes1, -5, and -7) and Hes-related proteins (Hey1, -2, and -L) are the best-characterized downstream targets. http://www.tkuhn.ch/bel2nanopub/RAg25eB99HY4m6FsmyxIAjqfHo3diYVC88b6J5TkKRT84#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16023591 http://www.tkuhn.ch/bel2nanopub/RAg25eB99HY4m6FsmyxIAjqfHo3diYVC88b6J5TkKRT84#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAg25eB99HY4m6FsmyxIAjqfHo3diYVC88b6J5TkKRT84#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16023591 http://www.tkuhn.ch/bel2nanopub/RAg25eB99HY4m6FsmyxIAjqfHo3diYVC88b6J5TkKRT84#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAg25eB99HY4m6FsmyxIAjqfHo3diYVC88b6J5TkKRT84#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAg25eB99HY4m6FsmyxIAjqfHo3diYVC88b6J5TkKRT84#_5 http://www.tkuhn.ch/bel2nanopub/RAg25eB99HY4m6FsmyxIAjqfHo3diYVC88b6J5TkKRT84#pubinfo http://www.tkuhn.ch/bel2nanopub/RAg25eB99HY4m6FsmyxIAjqfHo3diYVC88b6J5TkKRT84 http://purl.org/dc/terms/created 2014-07-03T14:30:36.859+02:00 http://www.tkuhn.ch/bel2nanopub/RAg25eB99HY4m6FsmyxIAjqfHo3diYVC88b6J5TkKRT84 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAg25eB99HY4m6FsmyxIAjqfHo3diYVC88b6J5TkKRT84 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234