http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#Head http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#assertion http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#provenance http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#assertion http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:1309468 http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:1097717 http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D006321 http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_2 http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_1 http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#assertion http://www.w3.org/2000/01/rdf-schema#label p(MGI:Casq1) -> r(MGI:Ankrd1) http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_4 http://www.w3.org/ns/prov#value Calsequestrin (CSQ) is the major Ca2+ binding protein of the cardiac sarcoplasmic reticulum (SR). Transgenic mice overexpressing CSQ at the age of 7 weeks exhibit concentric cardiac hypertrophy, and by 13 weeks the condition progresses to dilated cardiomyopathy. The present study used a differential display analysis to identify genes whose expressions are modulated in the CSQ-overexpressing mouse hearts to provide information on the mechanism of transition from concentric cardiac hypertrophy to failure. Cardiac ankyrin repeat protein (CARP), glutathione peroxidase (Gpx1), and genes which participate in the formation of extracellular matrix including decorin, TSC-36, Magp2, Osf2, and SPARC are upregulated in CSQ mouse hearts at 7 and 13 weeks of age compared to those of non-transgenic littermates. In addition, two novel genes without sequence similarities to any known genes are upregulated in CSQ-overexpressing mouse hearts. Several genes are downregulated at 13 weeks, including SR Ca2+-ATPase (SERCA2) and adenine nucleotide translocase 1 (Ant1) genes. Further, a functionally yet unknown gene (NM_026586) previously identified in the mouse wolffian duct is dramatically downregulated in CSQ mice with dilated hearts. Thus, CARP, Gpx1, and genes encoding extracellular matrix proteins may participate in the development of cardiac hypertrophy and fibrosis, and changes in SERCA2, Ant1, and NM_026586 mRNA expression may be involved in transition from concentric to dilated cardiac hypertrophy. http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12127059 http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12127059 http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#_4 http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0#pubinfo http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0 http://purl.org/dc/terms/created 2014-07-03T14:30:04.474+02:00 http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAg7ksM5SETl5driSZQuxEPmB3a_Sz653gSiuZPoOm5G0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234