. . . . . . . . . . . . . . . . . . . . . . . . "cat(p(HGNC:PLCG1)) -> (complex(p(HGNC:ITGB2),p(HGNC:ICAM1)) -> bp(GO:\"cell adhesion\"))" . "complex(p(HGNC:ITGB2),p(HGNC:ICAM1)) -> bp(GO:\"cell adhesion\")" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "A phospholipase C inhibitor, U73122, abrogated Rap1 activation triggered by both the TCR and SDF-1 (CXCL12). PLC-gamma1-deficient Jurkat T cells showed a marked reduction of TCR-triggered Rap1 activation and adhesion to intercellular adhesion molecule-1 (ICAM-1) mediated by LFA-1. In contrast, SDF-1-triggered Rap1 activation and adhesion were not affected in these cells. Transfection of these cells with an expression plasmid encoding PLC-gamma1 restored Rap1 activation by the TCR and the ability to adhere to ICAM-1, accompanied by polarized LFA-1 surface clustering colocalized with regulator of adhesion and polarization enriched in lymphoid tissues (RAPL)." . . "Selventa" . . . . "2014-07-03T14:30:19.430+02:00"^^ . . .