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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAgNZf8PBhrfxVL1B80dYnAVyA-Gxl7ViPF0Zr_kUIrRQ#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAgNZf8PBhrfxVL1B80dYnAVyA-Gxl7ViPF0Zr_kUIrRQ#_5 http://www.w3.org/ns/prov#value A previous study by our laboratory (9) showed that emphysematous lungs express MMP-1 whereas normal adult lungs do not. To determine whether this MMP-1 expression correlated with elevated mitogen-activated protein kinase, we analyzed these same human samples for p-ERK activity. Initial experiments were performed in the absence of the specific p42/p44 (ERK) substrate to determine endogenous protein phosphorylation in normal and emphysematous lungs. No difference was detected (Fig. 5A, left). However, when specific p-ERK activity was examined, significantly higher levels were detected in lung homogenates from patients with emphysema, compared with healthy control subjects (Fig. 5A, right: 1.9 ± 0.2-fold increase above normal lung, p = 0.02). We next assessed levels of ERK in eight human lung samples. Western blot analysis revealed that emphysematous lungs expressed higher p-ERK levels than normal lungs (Fig. 5B). http://www.tkuhn.ch/bel2nanopub/RAgNZf8PBhrfxVL1B80dYnAVyA-Gxl7ViPF0Zr_kUIrRQ#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14764579 http://www.tkuhn.ch/bel2nanopub/RAgNZf8PBhrfxVL1B80dYnAVyA-Gxl7ViPF0Zr_kUIrRQ#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAgNZf8PBhrfxVL1B80dYnAVyA-Gxl7ViPF0Zr_kUIrRQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14764579 http://www.tkuhn.ch/bel2nanopub/RAgNZf8PBhrfxVL1B80dYnAVyA-Gxl7ViPF0Zr_kUIrRQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAgNZf8PBhrfxVL1B80dYnAVyA-Gxl7ViPF0Zr_kUIrRQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAgNZf8PBhrfxVL1B80dYnAVyA-Gxl7ViPF0Zr_kUIrRQ#_5 http://www.tkuhn.ch/bel2nanopub/RAgNZf8PBhrfxVL1B80dYnAVyA-Gxl7ViPF0Zr_kUIrRQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAgNZf8PBhrfxVL1B80dYnAVyA-Gxl7ViPF0Zr_kUIrRQ http://purl.org/dc/terms/created 2014-07-03T14:30:20.305+02:00 http://www.tkuhn.ch/bel2nanopub/RAgNZf8PBhrfxVL1B80dYnAVyA-Gxl7ViPF0Zr_kUIrRQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAgNZf8PBhrfxVL1B80dYnAVyA-Gxl7ViPF0Zr_kUIrRQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234