@prefix dc: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAgxhVS5v97y8Ns45uR8mR8ry3EyPVYKd0McTaK3mhYzo> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAgxhVS5v97y8Ns45uR8mR8ry3EyPVYKd0McTaK3mhYzo#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:9644;
    a Protein: .
  
  sub:_2 hasAgent: sub:_3;
    a go:0016301 .
  
  sub:_3 geneProductOf: hgnc:11724;
    a Protein: .
  
  sub:_4 occursIn: mesh:D042783, species:9606;
    rdf:object sub:_2;
    rdf:predicate belv:directlyDecreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(HGNC:PTPN11) =| kin(p(HGNC:TEK))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved.";
    dce:title "BEL Framework Small Corpus Document";
    dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License";
    pav:authoredBy sub:_6;
    pav:version "1.6" .
  
  sub:_5 prov:value """HCPTPA overexpression inhibits VEGFinduced VEGFR2 autophosphorylation, EC migration,
and proliferation (46). High cell density-enhanced PTP1 (DEP- 1)/CD148 attenuates
phosphorylation of VEGFR2 in contact-inhibited confluent ECs (40). A small
molecule inhibitor of PTP1B enhances VEGF-induced VEGFR2 autophosphoryla- tion,
migration, and proliferation of EC, as well as neovascularization in a mouse matrigel
model (92). Angiopoietin-1 stimulates association of SHP-2 to the phosphorylated
Tie-2 receptor (47), which in turn inhibits PI3 kinase-dependent signaling
pathways leading to EC migration.""";
    prov:wasQuotedFrom pubmed:17511588 .
  
  sub:_6 rdfs:comment "support@belframework.org";
    rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:17511588;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dc:created "2014-07-03T14:29:33.900+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}