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Approximately 2000 hand curated statements drawn from 57 PubMeds.
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Copyright (c) 2011-2012, Selventa. All Rights Reserved.
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BEL Framework Small Corpus Document
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Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License
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HCPTPA overexpression inhibits VEGFinduced VEGFR2 autophosphorylation, EC migration,
and proliferation (46). High cell density-enhanced PTP1 (DEP- 1)/CD148 attenuates
phosphorylation of VEGFR2 in contact-inhibited confluent ECs (40). A small
molecule inhibitor of PTP1B enhances VEGF-induced VEGFR2 autophosphoryla- tion,
migration, and proliferation of EC, as well as neovascularization in a mouse matrigel
model (92). Angiopoietin-1 stimulates association of SHP-2 to the phosphorylated
Tie-2 receptor (47), which in turn inhibits PI3 kinase-dependent signaling
pathways leading to EC migration.
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Selventa
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2014-07-03T14:29:33.900+02:00
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