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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAh1KC9LzXXAVtWWYeaB7R-cThQZ1AhLChgcxcPSc4Hcc#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAh1KC9LzXXAVtWWYeaB7R-cThQZ1AhLChgcxcPSc4Hcc#_3 http://www.w3.org/ns/prov#value The activation of MAP-family kinase pathways leads to the activation of Mnk and hence eIF4E phosphorylation Mnk activation by oxidative stress leading to enhanced eIF4E phosphorylation may play a role in promoting stress-induced hyperproliferative diseases, such as smooth muscle cell proliferation and hypertrophy in cardiovascular disease, as the synthesis of several key regulators of cell growth has been shown to be held in check by moderation of eIF4E activity. http://www.tkuhn.ch/bel2nanopub/RAh1KC9LzXXAVtWWYeaB7R-cThQZ1AhLChgcxcPSc4Hcc#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15683719 http://www.tkuhn.ch/bel2nanopub/RAh1KC9LzXXAVtWWYeaB7R-cThQZ1AhLChgcxcPSc4Hcc#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAh1KC9LzXXAVtWWYeaB7R-cThQZ1AhLChgcxcPSc4Hcc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15683719 http://www.tkuhn.ch/bel2nanopub/RAh1KC9LzXXAVtWWYeaB7R-cThQZ1AhLChgcxcPSc4Hcc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAh1KC9LzXXAVtWWYeaB7R-cThQZ1AhLChgcxcPSc4Hcc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAh1KC9LzXXAVtWWYeaB7R-cThQZ1AhLChgcxcPSc4Hcc#_3 http://www.tkuhn.ch/bel2nanopub/RAh1KC9LzXXAVtWWYeaB7R-cThQZ1AhLChgcxcPSc4Hcc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAh1KC9LzXXAVtWWYeaB7R-cThQZ1AhLChgcxcPSc4Hcc http://purl.org/dc/terms/created 2014-07-03T14:30:31.310+02:00 http://www.tkuhn.ch/bel2nanopub/RAh1KC9LzXXAVtWWYeaB7R-cThQZ1AhLChgcxcPSc4Hcc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAh1KC9LzXXAVtWWYeaB7R-cThQZ1AhLChgcxcPSc4Hcc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234