. . . . . . . . . . . . . . . . . . . . . . "a(SCHEM:\"Pertussis toxins\") -| (kin(p(HGNC:FLT1)) -> gtp(p(HGNC:RAC1)))" . "kin(p(HGNC:FLT1)) -> gtp(p(HGNC:RAC1))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Surprisingly, pertussis toxin and overexpression of the free Gbetagamma-specific sequestering minigene hbetaARK1(495) also inhibit EGLT-mediated CDC42 and Rac1 activation completely. Moreover, pertussis toxin treatment also increases the intracellular Ca(2+) mobilization and inhibits the antiproliferation activity, thus suggesting that pertussis toxin-sensitive G proteins and the Gbetagamma subunits are involved in the signaling pathway of Flt-1 that down-regulates EC proliferation. Taken together, these results further expand our understanding of Flt-1-mediated antiproliferative activity in VPF/VEGF-stimulated endothelium." . . "Selventa" . . . . "2014-07-03T14:29:59.394+02:00"^^ . . .