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http://www.tkuhn.ch/bel2nanopub/RAh4rWyv1Sp0aLAl9I1KeWTY3ylssC3cdTrwIXvyPrCTo#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAh4rWyv1Sp0aLAl9I1KeWTY3ylssC3cdTrwIXvyPrCTo#_8 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAh4rWyv1Sp0aLAl9I1KeWTY3ylssC3cdTrwIXvyPrCTo#_7 http://www.w3.org/ns/prov#value Surprisingly, pertussis toxin and overexpression of the free Gbetagamma-specific sequestering minigene hbetaARK1(495) also inhibit EGLT-mediated CDC42 and Rac1 activation completely. Moreover, pertussis toxin treatment also increases the intracellular Ca(2+) mobilization and inhibits the antiproliferation activity, thus suggesting that pertussis toxin-sensitive G proteins and the Gbetagamma subunits are involved in the signaling pathway of Flt-1 that down-regulates EC proliferation. Taken together, these results further expand our understanding of Flt-1-mediated antiproliferative activity in VPF/VEGF-stimulated endothelium. http://www.tkuhn.ch/bel2nanopub/RAh4rWyv1Sp0aLAl9I1KeWTY3ylssC3cdTrwIXvyPrCTo#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11726672 http://www.tkuhn.ch/bel2nanopub/RAh4rWyv1Sp0aLAl9I1KeWTY3ylssC3cdTrwIXvyPrCTo#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAh4rWyv1Sp0aLAl9I1KeWTY3ylssC3cdTrwIXvyPrCTo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11726672 http://www.tkuhn.ch/bel2nanopub/RAh4rWyv1Sp0aLAl9I1KeWTY3ylssC3cdTrwIXvyPrCTo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAh4rWyv1Sp0aLAl9I1KeWTY3ylssC3cdTrwIXvyPrCTo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAh4rWyv1Sp0aLAl9I1KeWTY3ylssC3cdTrwIXvyPrCTo#_7 http://www.tkuhn.ch/bel2nanopub/RAh4rWyv1Sp0aLAl9I1KeWTY3ylssC3cdTrwIXvyPrCTo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAh4rWyv1Sp0aLAl9I1KeWTY3ylssC3cdTrwIXvyPrCTo http://purl.org/dc/terms/created 2014-07-03T14:29:59.394+02:00 http://www.tkuhn.ch/bel2nanopub/RAh4rWyv1Sp0aLAl9I1KeWTY3ylssC3cdTrwIXvyPrCTo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAh4rWyv1Sp0aLAl9I1KeWTY3ylssC3cdTrwIXvyPrCTo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234