sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "We report here that the phosphorylation of BAD at Ser-155 within the BH3 domain is a second phosphorylation-dependant mechanism that inhibits the death promoting activity of BAD. Phosphorylation at Ser-155, similar to phosphorylation at SER-112 and Ser-136, inhibits BAD-induced death-promoting activity but does so in a different manner. Phosphorylation at Ser-155 does not induce 14-3-3 binding and ctoplasmic sequestration but instead directly blocks BH3-dependent dimerization with Bcl-XL. The binding of Bcl-XL by the BH3 domain may cause Bcl-XL to release APAF-1 or regulate other Bcl-XL activites resulting in a caspase 9-initiated cascade of proteolysis and induction of apoptosis." ;
    prov:wasQuotedFrom pubmed:10837486 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:10837486 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}