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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAh54IaGqCxt-n6LRmhY1tHB0_qx72FA6U0L9UkwPLtm8#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAh54IaGqCxt-n6LRmhY1tHB0_qx72FA6U0L9UkwPLtm8#_4 http://www.w3.org/ns/prov#value We report here that the phosphorylation of BAD at Ser-155 within the BH3 domain is a second phosphorylation-dependant mechanism that inhibits the death promoting activity of BAD. Phosphorylation at Ser-155, similar to phosphorylation at SER-112 and Ser-136, inhibits BAD-induced death-promoting activity but does so in a different manner. Phosphorylation at Ser-155 does not induce 14-3-3 binding and ctoplasmic sequestration but instead directly blocks BH3-dependent dimerization with Bcl-XL. The binding of Bcl-XL by the BH3 domain may cause Bcl-XL to release APAF-1 or regulate other Bcl-XL activites resulting in a caspase 9-initiated cascade of proteolysis and induction of apoptosis. http://www.tkuhn.ch/bel2nanopub/RAh54IaGqCxt-n6LRmhY1tHB0_qx72FA6U0L9UkwPLtm8#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10837486 http://www.tkuhn.ch/bel2nanopub/RAh54IaGqCxt-n6LRmhY1tHB0_qx72FA6U0L9UkwPLtm8#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAh54IaGqCxt-n6LRmhY1tHB0_qx72FA6U0L9UkwPLtm8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10837486 http://www.tkuhn.ch/bel2nanopub/RAh54IaGqCxt-n6LRmhY1tHB0_qx72FA6U0L9UkwPLtm8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAh54IaGqCxt-n6LRmhY1tHB0_qx72FA6U0L9UkwPLtm8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAh54IaGqCxt-n6LRmhY1tHB0_qx72FA6U0L9UkwPLtm8#_4 http://www.tkuhn.ch/bel2nanopub/RAh54IaGqCxt-n6LRmhY1tHB0_qx72FA6U0L9UkwPLtm8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAh54IaGqCxt-n6LRmhY1tHB0_qx72FA6U0L9UkwPLtm8 http://purl.org/dc/terms/created 2014-07-03T14:29:51.220+02:00 http://www.tkuhn.ch/bel2nanopub/RAh54IaGqCxt-n6LRmhY1tHB0_qx72FA6U0L9UkwPLtm8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAh54IaGqCxt-n6LRmhY1tHB0_qx72FA6U0L9UkwPLtm8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234