http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#Head http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#assertion http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#provenance http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#pubinfo http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#assertion http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_2 http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0003824 http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11453 http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.ebi.ac.uk/chebi/searchId.do?chebiId=23965 http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_1 http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#assertion http://www.w3.org/2000/01/rdf-schema#label cat(p(HGNC:SULT1A1)) -| a(CHEBI:estradiol) http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_4 http://www.w3.org/ns/prov#value Sulfotransferase (SULT) 1A1 is involved in the inactivation and elimination of estrogens and catechol estrogens. A common functional polymorphism (Arg213His) has been linked in our previous study of postmenopausal Caucasian women to an elevated risk of breast cancer and the association appeared to be modified by factors related to high endogenous estrogen exposures. We further evaluated this polymorphism and levels of BMI and steroid hormones in association with breast cancer risk in a population-based case-control study of Chinese women, involving 1102 incident cases aged 25-64 years and 1147 age-matched population controls. The SULT1A1 genotype was not associated with overall breast cancer risk in this population. A possible association was suggested for postmenopausal breast cancer (adjusted odds ratio [OR] = 1.4, 95% CI = 0.9-2.1 for subject carrying the variant His allele). The SULT1A1 genotype was found to significantly modify postmenopausal breast cancer risk associated with a high BMI (>or=25 kg/m2) (p for interaction = 0.02), with an adjusted OR of 3.6 (95% CI = 1.5-8.7) for women with the Arg/His genotype compared with 1.1 (0.8-1.5) for women with the Arg/Arg genotype (no His/His genotype was identified in this study population). Similarly, the risk associated with a long duration (>or=30 years) of menstruation also substantially differed by the SULT1A1 genotype (p for interaction = 0.05), with an OR of 4.0 (95% CI = 1.3-12.8) for women with the Arg/His genotype and 1.4 (0.8-2.5) for women with the Arg/Arg genotype. Positive associations with blood levels of steroid hormones were also found generally to be more pronounced among women carrying the His allele. No similar effect modification was found for premenopausal breast cancer, however. These data suggest that the SULT1A1 Arg213His polymorphism may modify the effect of endogenous sex hormone exposures on postmenopausal breast cancer risk. http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16175316 http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16175316 http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#_4 http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE#pubinfo http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE http://purl.org/dc/terms/created 2014-07-03T14:30:38.270+02:00 http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAhK3vjEn4bHfzZagcMbuSXW1p6Mzcz5QYTyW7vHDQDdE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234