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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A#_5 http://purl.org/dc/elements/1.1/identifier Reactome Pathway http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A#_5 http://purl.org/dc/elements/1.1/title Reactome Pathway http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A#_5 http://purl.org/dc/elements/1.1/type Other http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A#_6 http://www.w3.org/ns/prov#value 4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone). 4-carboxycholesta-8(9),24-dien-3beta-ol and NAD+ react to form zymosterone (cholesta-8(9),24-dien-3-one), CO2, and NADH + H+. This reaction occurs in the endoplasmic reticulum, catalyzed by NSDHL (Caldas and Herman 2003). Defects in this enzyme are associated with CHILD syndrome (Congenital Hemidysplasia with Ichthyosiform nevus and Limb Defects) (Konig et al. 2000), but cholesterol biosynthesis in cells and tissues from affceted individuals has not been characterized. Instead, the mechanism and stoichiometry of the reaction are inferred from biochemical studies of partially purified rat enzyme (Rahimtula and Gaylor 1972). http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A#_5 http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A#_5 http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A#_6 http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A#pubinfo http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A http://purl.org/dc/terms/created 2014-07-03T14:29:44.834+02:00 http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAhLoTV2qQaUCXO-aQ-muJbAbOnVEnvLa5t_jv3RCVW6A http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234