. . . . . . . . . . . . . . . . "kin(complex(NCH:\"p85/p110 PI3Kinase Complex\")) -> kin(p(HGNC:PDPK1))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "At early developmental stages,SGK is first expressed in the decidua and yolk sac and is highly expressed in heart tissue, blood vessels and lung buds, suggesting a potential role for this protein kinase in heart development and or blood vessel formation [53]. As reviewed elsewhere [61-63], the phosphoinositide dependent protein kinase-1 (PDK1) is activated directly down-stream of PI 3-kinase [22, 28]. Full stimulation of SGK enzymatic activity requires the PDK-1 dependent phosphorylation at amino acid residue threonine 256 within the activation loop of SGK, and phosphorylation at serine 422 in the carboxyterminal domain, presumably by a PDK-1-like enzyme [22, 28]." . . "Selventa" . . . . "2014-07-03T14:30:11.216+02:00"^^ . . .