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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAhW-361XhvnFAZScyNpa6cYo8OgPFsPlXtr2nZa4uZCw#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAhW-361XhvnFAZScyNpa6cYo8OgPFsPlXtr2nZa4uZCw#_3 http://www.w3.org/ns/prov#value There is increasing evidence that histamine affects dendritic cell (DC) activation, maturation, and preference for Th1/Th2 differentiation. In this paper we report that histamine affects interleukin (IL)-12 and IL-6 production in an immature DC (iDC) line derived from murine spleen. Histamine treatment of iDC significantly increased the IL-12 p40 mRNA and protein levels compared to histamine untreated iDC. In the presence of tumor necrosis factor (TNF)-alpha histamine also increased IL-12 p40 and IL-6 production. However, histamine significantly decreased IL-12 p40 production by lipopolysaccharide (LPS)-stimulated DC in a concentration dependent manner. When expressions of histamine H1 (H1R) and H2 (H2R) receptors in DC were analyzed by RT-PCR, both receptors were down-regulated after LPS or TNF-alpha stimulation compared to unstimulated iDC. Histamine treatment significantly increased the expression of H2R mRNA in iDC and H1R mRNA in LPS-activated DC. However, histamine treatment decreased the expression of both histamine receptors in TNF-alpha-stimulated DC. Similar results were obtained by flow cytometry with FITC-conjugated histamine. These results demonstrate that histamine can regulate the expression of its own receptors and activate iDC, which may influence subsequent functional states of mature DC in a maturation signal-dependent manner. Consequently, histamine may contribute to an immune response outcome. http://www.tkuhn.ch/bel2nanopub/RAhW-361XhvnFAZScyNpa6cYo8OgPFsPlXtr2nZa4uZCw#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14575147 http://www.tkuhn.ch/bel2nanopub/RAhW-361XhvnFAZScyNpa6cYo8OgPFsPlXtr2nZa4uZCw#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAhW-361XhvnFAZScyNpa6cYo8OgPFsPlXtr2nZa4uZCw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14575147 http://www.tkuhn.ch/bel2nanopub/RAhW-361XhvnFAZScyNpa6cYo8OgPFsPlXtr2nZa4uZCw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAhW-361XhvnFAZScyNpa6cYo8OgPFsPlXtr2nZa4uZCw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAhW-361XhvnFAZScyNpa6cYo8OgPFsPlXtr2nZa4uZCw#_3 http://www.tkuhn.ch/bel2nanopub/RAhW-361XhvnFAZScyNpa6cYo8OgPFsPlXtr2nZa4uZCw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAhW-361XhvnFAZScyNpa6cYo8OgPFsPlXtr2nZa4uZCw http://purl.org/dc/terms/created 2014-07-03T14:30:17.670+02:00 http://www.tkuhn.ch/bel2nanopub/RAhW-361XhvnFAZScyNpa6cYo8OgPFsPlXtr2nZa4uZCw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAhW-361XhvnFAZScyNpa6cYo8OgPFsPlXtr2nZa4uZCw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234