@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAhW4fTLO5QpDVBQ3Vyvtaif9xm3kAG3Kuy_PNZb95thQ> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAhW4fTLO5QpDVBQ3Vyvtaif9xm3kAG3Kuy_PNZb95thQ#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0016791 .
  
  sub:_2 geneProductOf: hgnc:9642;
    a Protein: .
  
  sub:_3 hasAgent: sub:_4;
    a go:0016301 .
  
  sub:_4 geneProductOf: hgnc:6091;
    a Protein: .
  
  sub:_5 occursIn: mesh:D000273, mesh:D008099, species:9606;
    rdf:object sub:_3;
    rdf:predicate belv:decreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "phos(p(HGNC:PTPN1)) -| kin(p(HGNC:INSR))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_7;
    pav:version "1.4" .
  
  sub:_6 prov:value "Several kinases have been implicated in this process, including PI(3)K, Akt, glycogen synthase kinase (GSK)-3 and mammalian target of rapamycin (mTOR). Recent data indicate that obesity-induced attenuation of insulin signalling might arise from the sequential activation of protein kinase C (PKC) and inhibitor of nuclear factor-kB (IkB) kinase, although the details of this pathway have not been elucidated Knockout of PTP1B leads to increased tyrosine phosphorylation of the insulin receptor and IRS proteins in muscle and improved insulin sensitivity";
    prov:wasQuotedFrom pubmed:11742412 .
  
  sub:_7 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:11742412;
    prov:wasDerivedFrom beldoc:, sub:_6 .
}

sub:pubinfo {
  this: dcterms:created "2014-07-03T14:29:59.692+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}