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[Sitosterolemia induced in Abcg5- and Abcg8-deficient mice fed a high plant sterol diet resulted in accumulation of free sterols in platelet plasma membranes, leading to hyperactivatable platelets characterized by constitutive binding of fibrinogen to its ?IIb?3 integrin receptor, internalization of the ?IIb?3 complex, generation of platelet-derived microparticles, and changes in the quantity and subcellular localization of filamin.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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