http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#Head http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#assertion http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#provenance http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#assertion http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_2 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=8592 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_3 http://www.selventa.com/vocabulary/variantOf http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9829 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00696 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D003593 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_4 http://semanticscience.org/resource/SIO_000255 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_5 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_3 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyIncreases http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_1 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_5 http://purl.org/dc/terms/subject TextLocation http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#value Review http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(HGNC:PAK3)) => p(HGNC:RAF1,pmod(P,S,338)) http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#provenance http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 2000 hand curated statements drawn from 57 PubMeds. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All Rights Reserved. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_7 http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/version 1.6 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_6 http://www.w3.org/ns/prov#value Raf is also phosphorylated at other serine and threonine residues, the most important of which are S338 and tyrosine (Y) 341, which are situated adjacent to the C-Raf kinase domain.140 Phosphorylation of these residues relieves the inhibitory effects of the regulatory domain on the kinase domain.141 S338, which is the evolutionarily conserved PAK phosphorylation site that resides on the amino-terminal side of the kinase domain, is critical for Raf activation.134-136,140,142 This site is also phosphorylated in response to stimulation by growth factors, integrins, Ras, PAK1, and PAK3.78,136,143 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16170185 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_7 http://www.w3.org/2000/01/rdf-schema#comment support@belframework.org http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16170185 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#_6 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg http://purl.org/dc/terms/created 2014-07-03T14:29:30.548+02:00 http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAi5Ztqz-qsFD6jNmeNRThM3vqT0Mh4AojK2HQvH2brLg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234