sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." ;
    dce:title "BEL Framework Small Corpus Document" ;
    dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" ;
    pav:authoredBy sub:_6 ;
    pav:version "1.6" .
  sub:_5 prov:value """PI3K-dependent activation of PKB is an intermediary in the phosphorylation and inactivation
of GSK-3 induced by insulin and other growth factors (10, 12, 14). Insulin
and IGF-1 efficiently activate the PI3K pathway in NIH 3T3 and Rat1 cells,
respectively. GSK-3 phosphorylation induced by insulin and IGF-1 were eliminated
by pretreatment with the PI3K inhibitors wortmannin or LY294002. In contrast,
the effects of 8-Br-cAMP or forskolin on GSK-3 phosphorylation in these cell lines
were not altered by inhibition of PI3K activity with wortmannin or LY294002 (Fig.
2A), excluding the possibility that PKA induces GSK-3 phosphorylation through
activation of PI3K.""" ;
    prov:wasQuotedFrom pubmed:11035810 .
  sub:_6 rdfs:comment "support@belframework.org" ;
    rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:11035810 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}