@prefix dc: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix nch: <http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix hasAnnotation: <http://semanticscience.org/resource/SIO_000255> .
@prefix atcc: <http://www.lgcstandards-atcc.org/Products/All/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  nch:p85%2Fp110%20PI3Kinase%20Complex a ProteinComplex: .
  
  sub:_1 geneProductOf: hgnc:5464;
    a Protein: .
  
  sub:_2 hasAgent: nch:p85%2Fp110%20PI3Kinase%20Complex;
    a go:0016301 .
  
  sub:_3 occursIn: mesh:D002460, mesh:D007668, atcc:CRL-2210.aspx, species:10116;
    hasAnnotation: sub:_4;
    rdf:object sub:_2;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:_4 dc:subject "TextLocation";
    rdf:value "Results" .
  
  sub:assertion rdfs:label "p(HGNC:IGF1) -> kin(complex(NCH:\"p85/p110 PI3Kinase Complex\"))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved.";
    dce:title "BEL Framework Small Corpus Document";
    dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License";
    pav:authoredBy sub:_6;
    pav:version "1.6" .
  
  sub:_5 prov:value """PI3K-dependent activation of PKB is an intermediary in the phosphorylation and inactivation
of GSK-3 induced by insulin and other growth factors (10, 12, 14). Insulin
and IGF-1 efficiently activate the PI3K pathway in NIH 3T3 and Rat1 cells,
respectively. GSK-3 phosphorylation induced by insulin and IGF-1 were eliminated
by pretreatment with the PI3K inhibitors wortmannin or LY294002. In contrast,
the effects of 8-Br-cAMP or forskolin on GSK-3 phosphorylation in these cell lines
were not altered by inhibition of PI3K activity with wortmannin or LY294002 (Fig.
2A), excluding the possibility that PKA induces GSK-3 phosphorylation through
activation of PI3K.""";
    prov:wasQuotedFrom pubmed:11035810 .
  
  sub:_6 rdfs:comment "support@belframework.org";
    rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:11035810;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dc:created "2014-07-03T14:29:34.673+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}